Blogging with Parkinson's

A personal perspective on Young Onset Parkinson's

Human dopamine neurons with Parkin mutation grown in laboratory

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Image nabbed from http://neuralwiki.org and slightly altered. File originated from Wikimedia Commons.

A petri dish, often used in laboratories to grow things in vitro (literally, "in glass").

The BBC have a text article on this development. You can read it here. Basically, scientists in the US have managed to generate dopamine neurons in culture – and not just any old dopamine neurons, either. These are a mutated type that occur in some genetic forms of Parkinson’s Disease. The process involved skin cells collected from patients with the parkin mutation; the skin cells were induced to grow into the required neurons using recently developed stem cell technology.

“This is the first time that human dopamine neurons have ever been generated from Parkinson’s disease patients with parkin mutations,” said Dr Jian Feng who led the investigations.

“Before this, we didn’t even think about being able to study the disease in human neurons.

“The brain is so fully integrated. It’s impossible to obtain live human neurons to study.”

– from the BBC article

Obviously, any findings made using these cells are going to be most relevant to  people with the Parkin mutation. But it may be that discoveries may ensue that are pertinent to everybody with Parkinson’s. After all, these are deficient  dopamine neurons. Everybody with Parkinson’s has a problem with their dopamine neurons. We can also hope that the techniques used to grow these cells in vitro can be extended to grow other neurons with specific mutations.

The abstract for the scientific paper, published in the journal Nature Communications does, indeed, suggest potential beyond the specific parkin mutation:

[…] The results suggest that parkin controls dopamine utilization in human midbrain DA neurons by enhancing the precision of DA neurotransmission and suppressing dopamine oxidation. Thus, the study provides novel targets and a physiologically relevant screening platform for disease-modifying therapies of PD.

“Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells”, Houbo Jiang, Yong Ren, Eunice Y. Yuen, Ping Zhong, Mahboobe Ghaedi, Zhixing Hu, Gissou Azabdaftari, Kazuhiro Nakaso, Zhen Yan & Jian Feng

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2 thoughts on “Human dopamine neurons with Parkin mutation grown in laboratory

  1. Hey I just discovered your blog and came across this post. The lead researcher in this work, is Dr. Jian Feng, a professor I had for physiology a couple years ago. The school is University at Buffalo. If you would like the full-text version of this publication, feel free to download it from my Dropbox http://db.tt/MLfyE0eV . I am currently a pharmacy student and my mother has PD, diagnosed in her mid 40s. Any full-text articles on any site I can probably get free access to, and if it will inspire some writing or thinking or give anyone some hope, then let me know and I’ll see what I can do for you.

    On a side note, there was also recently (within the past couple days) a “Letter to the Editor” sort of article in the New England Journal of Medicine in response to Tai-Chi in PD, and I saw that you wrote about that specifically.
    Keep up the good work!
    – Kevin

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